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Adding hyaluronic acid to professional mechanical plaque removal provides metabolic benefit without additional local periodontal improvement.
As per the findings of a study by Reem Al-Abbadi et al., topical hyaluronic acid (HA) gel, when used alongside professional mechanical plaque removal (PMPR), may offer additional metabolic benefits for patients with type 2 diabetes (T2D) and periodontitis. This randomized controlled trial included 26 well-controlled T2D patients (glycated hemoglobin [HbA1c] < 7%) diagnosed with stage-II, grade B periodontitis. Participants were segregated into two groups:
Clinical attachment level (CAL) served as the primary outcome. On the other hand, probing pocket depth (PPD), gingival recession depth (GRD), bleeding on probing (BOP), O’Leary plaque index (PI), HbA1c, defect depth (DD), and radiographic bone density (RBD) were evaluated as secondary outcomes at baseline, 3 months, and 6 months.
Both treatment groups exhibited remarkable improvements in CAL, PPD, BOP, PI, DD, and RBD over 6 months (p < 0.05). However, no statistically significant intergroup differences were noted for these periodontal parameters. Interestingly, a prominent reduction in HbA1c levels was observed only in the PMPR + HA group (p < 0.05), suggesting a possible systemic effect of adjunctive HA application.
For T2D patients with periodontitis, PMPR alone yields substantial clinical benefits. However, the addition of topical HA gel may further enhance metabolic outcomes by improving glycemic control. These findings highlight the potential of HA as a valuable adjunct in periodontal therapy for diabetic individuals.
BMC Oral Health
Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial
Reem Al-Abbadi et al.
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