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The AGT M235T TT genotype and T allele significantly heighten the risk of ischemic heart disease in hypertension sufferers, especially those with dyslipidemia.
A hospital-based case-control study has identified a significant connection between a genetic variation in the angiotensinogen (AGT) gene and the risk of ischemic heart disease (IHD) among individuals with hypertension. The findings underscore the potential role of the AGT M235T (rs699) polymorphism as a genetic marker for cardiovascular vulnerability.
While hypertension and dyslipidemia are well-established cardiovascular risk factors, their interaction with genetic predispositions remains under investigation. To better understand this link, scientists carried out a study involving 70 hypertensive people suffering from ischemic heart disease and 70 age- and sex-matched healthy controls. Volunteers underwent comprehensive clinical evaluations, and blood samples were analyzed for both biochemical parameters and genetic markers.
Genotyping was carried out using polymerase chain reaction followed by restriction fragment length polymorphism (RFLP) analysis and agarose gel electrophoresis to determine specific AGT M235T genotypes. Results revealed that the AGT-TT genotype was considerably more common among IHD patients compared to healthy controls (Odds Ratio [OR] = 3.35). Similarly, individuals carrying the T allele showed a higher likelihood of developing IHD (OR = 2.50).
Additionally, dyslipidemia—an imbalance in blood lipid levels—was notably prevalent among the IHD group (OR = 4.57), reinforcing the combined impact of metabolic and genetic risk factors.
The researchers concluded that the AGT M235T TT genotype and T allele can serve as genetic risk factors for coronary artery disease or coronary heart disease in hypertensive individuals. The strong link between dyslipidemia and IHD in this group underscores the importance of early lipid and genetic screening to identify those at heightened cardiovascular risk.
Ethiopian Journal of Health Sciences
Angiotensinogen M235T Gene Polymorphism and Risk of Ischemic Heart Disease Complication among Patients with Hypertension in the Ethiopian Population
Addisu Melake et al.
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