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Montelukast-levocetirizine combination improves nasal symptoms and overall disease control in patients with allergic rhinitis complicated by asthma.
A systematic review and meta-analysis has revealed that combining montelukast with levocetirizine offers powerful relief for patients battling allergic rhinitis alongside asthma. The study provides strong, evidence-based support for a treatment strategy that goes beyond traditional single-drug therapy.
Min Shao and other researchers sought to evaluate both the efficacy and safety of this combination therapy, offering clinicians an evidence-based approach to managing these coexisting conditions. Multiple databases—including PubMed, Web of Science, Cochrane Library, WANFANG DATA, CNKI, and the Chinese BioMedical Literature Database—were explored to identify relevant studies. Eligibility criteria were applied to screen records, and 2 independent investigators reviewed titles, abstracts, and full texts to select studies for inclusion.
Overall, 6 studies involving 2,950 patients were included. Results showed a pooled nasal symptom score (NSS) of -1.28, indicating a remarkable improvement in nasal symptoms with the combined therapy. In controlled trials, the standardized mean difference in NSS for patients receiving montelukast + levocetirizine was -2.56, demonstrating that the combination was markedly more beneficial than control treatments.
The analysis also confirmed the safety profile of the therapy, suggesting it is well-tolerated by patients. In conclusion, montelukast combined with levocetirizine significantly ameliorates nasal symptoms in allergic rhinitis and asthma sufferers, outperforming monotherapy while maintaining a favorable safety profile.
Journal of Asthma
Efficacy and safety of montelukast-levocetirizine combination therapy in combined allergic rhinitis and asthma syndrome: a systematic review and meta-analysis
Min Shao et al.
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