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Topical pregabalin gel (10%) effectively minimizes post-bleaching sensitivity while preserving bleaching results.
According to the findings of a randomized clinical trial, a 10% pregabalin gel may successfully reduce dental sensitivity following teeth whitening procedures—without compromising the bleaching outcome. The goal was to explore topical pregabalin gel's efficiency in tackling post-bleaching sensitivity. A total of 75 healthy adult volunteers were randomly assigned to:
Before undergoing in-office dental bleaching with 35% hydrogen peroxide, each subject received a 10-minute application of the assigned gel. The bleaching process consisted of 3 sessions, spaced 1 week apart. To assess the impact of the gels, researchers used visual analog scale (VAS) to measure participants' perceived dental sensitivity over a 21-day follow-up. The assessments were recorded on days 1, 8, and 15 post-treatment. In addition to tracking sensitivity, the study also examined tooth color changes via multiple parameters:
Color and brightness measurements were taken at the start of the study and again 7 days after the final bleaching session. The results demonstrated a clear benefit for those who received either the pregabalin gel or the conventional potassium nitrate/sodium fluoride gel.
Hence, 10% pregabalin gel is beneficial in diminishing dental sensitivity following whitening treatments involving high-concentration hydrogen peroxide. Moreover, it does so without diminishing the cosmetic results. The study supports its use as a promising alternative for patients seeking a more comfortable whitening experience.
Clinical Oral Investigations
Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial
Gabriela Monteiro Barbosa Xavier et al.
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