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Supplementing vitamin D improves insulin resistance, inflammation, lipid profile, androgen levels, and IVF outcomes in women with PCOS, while effects on ovulation and pregnancy rates remain inconsistent.
A new narrative review highlights the significant role of vitamin D in influencing metabolic, hormonal, and reproductive outcomes in women with polycystic ovary syndrome (PCOS), a common endocrine disorder impacting 15–20% of women of reproductive age.
The review was executed using the PubMed database and included clinical trials, observational studies, and experimental research. Search terms focused on PCOS, vitamin D, fertility, insulin resistance, and in vitro fertilization (IVF). As a narrative review, no original patient data were included.
As per the evidence from the included studies, vitamin D supplementation was associated with:
Additionally, higher serum and follicular fluid vitamin D levels were also linked to:
However, the evidence remains inconsistent regarding ovulation rates and pregnancy outcomes, highlighting the need for further large-scale, controlled studies. The review reinforces vitamin D as a potential modifiable factor in PCOS management, particularly in improving metabolic dysfunction and assisted reproductive outcomes. Given its high deficiency rates and biological relevance, screening and correcting vitamin D levels may offer a supportive strategy in optimizing fertility and endocrine health in PCOS.
Quality in Sport
Vitamin D and Reproductive Dysfunction in Polycystic Ovary Syndrome: Metabolic, Hormonal and Fertility Implications
Anna Bogacka et al.
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