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This research investigated the impact of applying 0.8% hyaluronic acid (HA) gel alongside open flap debridement (OFD) on clinical outcomes and biomarkers in the gingival crevicular fluid (GCF) of periodontitis-affected individuals.
Combining 0.8% hyaluronic acid gel with open flap debridement offers additional therapeutic benefits in modulating key inflammatory biomarkers in stage III periodontitis, outperforming open flap debridement alone.
This research investigated the impact of applying 0.8% hyaluronic acid (HA) gel alongside open flap debridement (OFD) on clinical outcomes and biomarkers in the gingival crevicular fluid (GCF) of periodontitis-affected individuals.
In this split-mouth study, 18 patients with Stage III Grade B or C periodontitis were enrolled. Quadrants were randomly allocated to the test group (OFD + 0.8% HA gel) or the control group (OFD alone). GCF samples and clinical assessments were examined at baseline, pre-surgery (T1), 1 month (T2), and 6 months (T3) after surgery. Utilizing enzyme-linked immunosorbent assay, the GCF levels of interleukin (IL)-6, IL-8, IL-10, IL-17A, total antioxidant status (TAS), and total oxidant status (TOS) were measured.
Within both groups, treatment led to remarkable reductions in GCF IL-6, IL-8, IL-17A, and TOS, and increases in IL-10 and TAS at T1, T2, and T3 compared to baseline. The test group exhibited substantially higher IL-10 levels at T2 and T3 and lower IL-17A levels at T3 compared to controls. In this randomized clinical trial, no pivotal differences were noted between groups for IL-6, IL-8, TAS, or TOS at any time point.
The adjunctive use of 0.8% HA gel with OFD positively modulated GCF IL-10 and IL-17A levels in patients with severe periodontitis.
Clinical Oral Investigations
Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis patients: a randomized, split-mouth clinical trial
Aslı Şener et al.
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