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This clinical study investigated the effectiveness of a combined treatment approach using photodynamic therapy (PDT) and fractional CO2 laser treatment for managing onychomycosis.
Combined photodynamic therapy and fractional CO2 laser treatment delivers significantly better clinical and mycological cure rates in onychomycosis than either treatment alone.
This clinical study investigated the effectiveness of a combined treatment approach using photodynamic therapy (PDT) and fractional CO2 laser treatment for managing onychomycosis.
A total of 45 patients diagnosed with onychomycosis were enrolled and randomly divided into 3 treatment groups:
Effectiveness was measured via clinical evaluation, mycological testing, and patient satisfaction scores.
The combination therapy group demonstrated superior effectiveness, with 86.7% showing negative fungal test results and 26.7% achieving complete nail clearance. Patient satisfaction levels were comparable across all groups (p = 0.198).
PDT + fractional CO2 laser treatment demonstrated superior efficacy when compared to single-modality treatments in improving clinical and mycological outcomes in onychomycosis. Integrating this dual-modality approach into dermatology practice may substantially improve treatment success for those with persistent or difficult-to-treat fungal nail infections.
Journal of Cosmetic Dermatology
Assessing the Therapeutic Efficacy of Photodynamic Therapy, Fractional CO2 Laser and Its Combination in the Treatment of Onychomycosis
Hamed Abdou et al.
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