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This randomized clinical trial examined whether a micronutrient supplement combined with probiotics can enhance follicular development and oocyte retrieval outcomes in normoresponder women undergoing controlled ovarian hyperstimulation for oocyte donation programs in assisted reproductive technology (ART).
Probiotic–micronutrient supplementation during controlled ovarian hyperstimulation significantly increases follicle count and oocyte yield in normoresponder oocyte donors.
This randomized clinical trial examined whether a micronutrient supplement combined with probiotics can enhance follicular development and oocyte retrieval outcomes in normoresponder women undergoing controlled ovarian hyperstimulation for oocyte donation programs in assisted reproductive technology (ART).
A total of 196 normoresponder oocyte donors were randomly assigned to receive either a probiotic–micronutrient supplement or placebo for at least 30 days prior to and during controlled ovarian hyperstimulation. Researchers evaluated follicle development, number of retrieved oocytes, and metaphase II (MII) oocyte quality, using both intention-to-treat (ITT) and per-protocol (PP) analyses.
Result
(A) ITT analysis
Women receiving the supplement illustrated remarkably improved follicular development, including higher total follicle count and mature follicles ≥16 mm, compared with placebo. However, the mean number of good-quality MII oocytes did not differ considerably between groups (Table 1).
(B) PP analysis
Among 79 women who adhered fully to the supplementation protocol, the benefits became more pronounced. The probiotic–micronutrient group achieved considerably higher oocyte retrieval outcomes, including total oocytes retrieved, mature MII oocytes, and good-quality MII oocytes (Table 2).
Supplementation with a probiotic-micronutrient formulation boosted follicular development and oocyte yield in normoresponder women undergoing controlled ovarian hyperstimulation for oocyte donation, particularly when taken as per the recommended protocol. While these findings highlight potential benefits for ART and fertility treatment outcomes, further studies are needed to substantiate the results and guide clinical recommendations for oocyte donation programs.
Journal of Assisted Reproduction and Genetics
Ovovid trial: the effect of a probiotic micronutrients supplement on oocyte retrieval and quality in oocyte donors. A double blind, randomized controlled trial
Silvia Bontá et al.
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