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Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease associated with pain, burning sensation, and persistent lesions.
Topical clobetasol and betamethasone, both combined with clotrimazole, show comparable efficacy in reducing lesion size and burning sensation in oral lichen planus.
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease associated with pain, burning sensation, and persistent lesions. With an unclear etiology, current treatment strategies emphasize symptom control, immune modulation, and inflammation reduction, typically using topical corticosteroids with antifungal agents. This study aimed to compare the clinical efficiency of topical clobetasol propionate 0.05% vs. betamethasone 0.05%, both combined with clotrimazole 1% in OLP.
In this randomized clinical trial, 30 OLP patients were segregated into:
Clinical outcomes were evaluated at 2 and 4 weeks using:
Both Group A and Group B illustrated remarkable improvement in lesion size and burning sensation, with no prominent difference between the two regimens at 4 weeks (Table 1).
Both clobetasol and betamethasone, when combined with clotrimazole, yielded equivalent clinical benefits in OLP care, including reduction in lesion size and relief from burning sensation. These results support their use as potent and interchangeable therapeutic options, with selection guided by cost, availability, patient tolerance, and clinician preference.
Cureus
A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole in the Management of Oral Lichen Planus
Pratima Soni et al.
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