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Impaired central thyroid hormone sensitivity is linked to increased triglyceride levels and a higher risk of hypertriglyceridemia in euthyroid individuals.
A study led by Yu Gong et al. has revealed a significant association between impaired central thyroid hormone sensitivity and hypertriglyceridemia (HTG) in individuals with normal thyroid function. The findings suggest that central thyroid hormone resistance may serve as an independent risk factor for raised triglyceride (TG) levels.
The study analyzed data from 833 randomly selected adults undergoing routine physical examinations. Researchers measured a wide range of biochemical parameters, including thyroid hormones, liver and kidney function markers, blood glucose, and lipid profiles. Central thyroid hormone sensitivity was assessed via 3 indices: the thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI), and thyrotropin thyroxine resistance index (TT4RI).
Using advanced statistical models, including smooth curve fitting, threshold effect analysis, and trend tests within multiple regression equations, the team explored the connection between central thyroid hormone sensitivity and TG levels. Key findings indicated that TSHI showed a positive correlation with TG (β=0.158). Similarly, TT4RI (β=0.018, inflection point: 25.809) and TFQI (β=0.798, inflection point: -0.194) were positively associated with TG levels before reaching their respective inflection points.
Subgroup analyses revealed that these associations were especially notable in females, males, individuals younger than 65 years, and those with a body mass index below 28 kg/m². For instance, in females, TT4RI and TFQI showed significant positive correlations with TG levels (TT4RI β=0.026; TFQI β=0.780). In males, TFQI illustrated a strong association (β=1.954). Trend analyses further emphasized that higher quartiles of TT4RI (odds ratio [OR] = 1.321) and TSHI (OR=1.253) were linked to an increased risk of HTG.
Each standard deviation increase in TT4RI raised the odds of HTG by 36.5% (OR=1.365), while each standard deviation increase in TSHI corresponded to a 19.1% higher risk (OR=1.191). Thus, reduced central thyroid hormone sensitivity is closely linked with higher TG levels in euthyroid adults, particularly in those under 65 years and with lower body mass index. These findings highlight the potential role of central thyroid hormone resistance as an independent risk factor for HTG, opening avenues for more targeted metabolic risk assessment and management in clinical practice.
Frontiers in Endocrinology
Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population
Yu Gong et al.
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