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Prenatal and postnatal choline supplementation show potential benefits for memory, cognition, and attention in children exposed to alcohol in utero.
A systematic review and meta-analysis suggests that choline supplementation, administered either before or after birth, may offer neurocognitive benefits to children whose mothers consumed alcohol during pregnancy. The goal was to examine the impact of choline on neurodevelopmental outcomes in alcohol-exposed pregnancies.
In this study, researchers systematically searched Medline, Embase, and the Cochrane Library for suitable trials. A total of 5 trials were included, encompassing both prenatal and postnatal nutritional support strategies. The team conducted meta-analyses with the aid of standardized mean difference (SMD) along with 95% confidence intervals (CI) and also employed a random-effects model. They further incorporated Bayesian modeling with Markov chain Monte Carlo methods for estimating the posterior probability of benefit (Pr) for each outcome.
Key findings:
While prenatal supplementation appears to benefit memory, postnatal supplementation may aid general cognition.This review highlights the potential role of nutritional strategies, such as choline, in public health efforts to minimize the impact of fetal alcohol spectrum disorders and improve long-term outcomes for the affected children.
Pediatrics & Neonatology
Does supplementation of choline during or after pregnancies exposed to alcohol improve neurocognitive development of children? A meta-analysis
Gabriel M. Lino et al.
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