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Sputum retention is a major barrier to recovery in pneumonia-affected children.
Mechanical vibration-assisted sputum clearance markedly improves clinical recovery, symptom resolution, lung function, blood gas parameters, and reduces inflammation in children with pneumonia.
Sputum retention is a major barrier to recovery in pneumonia-affected children. This randomized controlled trial explored the added therapeutic value of mechanical vibration-assisted sputum clearance (MVSC) when used alongside conventional pharmacological therapy and constructed a nomogram to guide personalized treatment settings.
In total, 160 pediatric pneumonia patients were evenly randomized into two groups: one received standard pharmacologic therapy, while the other received additional MVSC. Clinical improvement (categorized as “markedly improved” or “improved”), symptom resolution times, pulmonary function, blood gas metrics, and inflammatory markers were recorded both prior to and after treatment. For identifying key predictors of treatment response, LASSO regression was employed.
The MVSC group illustrated a markedly higher clinical improvement rate when compared to the control group (Table 1).
Additionally, this group experienced quicker resolution of symptoms (cough, fever, pulmonary rales) and shorter hospital stays. Notable improvements in lung function parameters (forced expiratory volume in 1 second [FEV1], forced expiratory volume in 1 second to forced vital capacity ratio [FEV1/FVC]), blood gas values (arterial oxygen partial pressure [PaO2], arterial carbon dioxide partial pressure [PaCO2], pH), and reductions in inflammatory biomarkers (C-reactive protein [CRP], procalcitonin) were also observed. A predictive nomogram incorporating age, chest circumference, moist rales, illness severity, vibration frequency, and pressure settings was developed to tailor MVSC therapy. This tool illustrated strong predictive performance with an AUC of 0.943.
Incorporating MVSC into standard treatment regimens remarkably improved clinical outcomes in children with pneumonia. Thus, the developed nomogram offers a reliable approach to customizing MVSC settings for better therapeutic efficacy.
Frontiers in Pediatrics
Effectiveness of mechanical vibration-assisted sputum clearance in pediatric pneumonia: a randomized controlled trial with development of an intelligent parameter optimization model
Sujing Xue et al.
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