Categories
Change Password!
Reset Password!
Addressing endometrial dysbiosis boosts conception rates in women with recurrent implantation failure.
A new study has highlighted the significant impact of endometrial dysbiosis (ED) on pregnancy outcomes in women with recurrent implantation failure (RIF), revealing the potential of personalized treatment strategies based on microbiome analysis. The study involved 73 women with RIF, all of whom underwent three diagnostic evaluations: hysteroscopy, endometrial CD138 immunostaining (to detect chronic endometritis or CE), and next-generation sequencing-based endometrial microbiome testing (to detect ED).
CE was detected in 56.2% of cases via hysteroscopy and in 49.3% via the CD138 test, while ED was detected in 53.4% of cases, marked by a reduction in Lactobacillus species. Despite the overlap in diagnostic goals, the results illustrated no vital correlation among the three tests, indicating that each test identifies a distinct subset of patients. Treatment was offered according to diagnosis: those with CE were treated with antibiotics, and those with ED received both antibiotics and vaginal Lactobacillus probiotics. The outcomes were striking—88.9% of ED sufferers achieved a clinical pregnancy following treatment, substantially higher than the pregnancy rate in those without ED (p = 0.021).
Furthermore, multivariate analysis revealed that ED was strongly linked with clinical pregnancy, with an odds ratio (OR) of 6.29 (p = 0.031). The study underscores the importance of individualized diagnostics in RIF, suggesting that ED—when diagnosed via microbiome testing—may serve as a key biomarker for selecting those who could benefit most from combined antibiotic and probiotic therapy. While CE and ED are both contributors to implantation failure, this research suggests that addressing ED specifically may arouse markedly improved reproductive outcomes.
Scientific Reports
Comparison of diagnostic tests for chronic endometritis and endometrial dysbiosis in recurrent implantation failure: Impact on pregnancy outcomes
Daiki Hiratsuka et al.
Comments (0)