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Diabetic neuropathy substantially impairs cognitive function, with women experiencing greater deficits and a potential link to Alzheimer’s disease.
A recent analysis has revealed that diabetic peripheral neuropathy (DPN) — a common complication of diabetes — markedly impairs cognitive function, with women disproportionately affected. Researchers analyzed 55 studies comparing cognitive performance in diabetic patients with and without DPN, examining memory, processing speed, and olfactory function, while also considering gender differences, psychological factors, and links to Alzheimer’s disease (AD).
The research examined multiple cognitive domains using standardized assessments, including memory tests, processing speed evaluations, and olfactory function measures. Findings revealed that those with DPN show notably greater cognitive deficits as opposed to diabetic sufferers without neuropathy and healthy controls. Memory and processing speed were particularly affected, highlighting the extensive neurological impact of DPN.
Gender differences emerged as a profactor. Women with DPN were found to experience more severe cognitive dysfunction and reported higher levels of painful neuropathy compared to men, underscoring the importance of gender-specific diagnostic and treatment strategies. The study also monitored the potential connection between peripheral neuropathy and AD. Researchers analyzed nerve conduction velocities and the presence of amyloid protein deposits, identifying potential links between DPN-related nerve damage and AD pathology.
Poor glycemic control was recognized as a major contributor, exacerbating both neuropathic pain and cognitive impairment. Psychological and socioeconomic factors were shown to play a fundamental role in the experience and management of neuropathic pain. Anxiety, depression, and socioeconomic challenges were linked to worsened cognitive outcomes and more severe neuropathic symptoms, emphasizing the requisition for comprehensive, multifaceted care strategies.
The authors stress the importance of integrated strategies that tackle both mental and physical health in DPN sufferers. The findings highlight that cognitive impairment in DPN is not uniform; women are disproportionately affected, and there is a concerning overlap with Alzheimer’s pathology. Effective management must consider glycemic control, mental health support, and gender-specific interventions to enhance patient outcomes.
Biochimica et Biophysica Acta: Molecular Basis of Disease
Exploring the cognitive impacts of diabetic neuropathy: a comprehensive review
Maamoon Mian et al.
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