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Frozen shoulder (scapulohumeral periarthritis) is a painful musculoskeletal disorder that limits shoulder mobility and quality of life.
Celecoxib delivers comparable pain relief to loxoprofen in frozen shoulder patients, while outperforming loxoprofen in reducing nocturnal pain and improving night-time comfort.
Frozen shoulder (scapulohumeral periarthritis) is a painful musculoskeletal disorder that limits shoulder mobility and quality of life. This randomized study explored the pain-relieving efficacy of celecoxib and loxoprofen (nonsteroidal anti-inflammatory drugs [NSAIDs]) for frozen shoulder management.
Patients presenting with pain as the primary symptom of frozen shoulder were randomly allocated to receive either celecoxib 100 mg twice daily (n = 37) or loxoprofen 60 mg three times daily (n = 33). Treatment was given for 1–2 weeks. Pain severity was assessed before and after therapy using a visual analog scale (VAS; 0–5).
Both celecoxib and loxoprofen resulted in statistically significant reductions in shoulder pain (Table 1).
Importantly, nocturnal pain resolution was observed in a remarkably higher proportion of patients treated with celecoxib (71.4%) compared with those receiving loxoprofen (36.8%), indicating superior control of night-time frozen shoulder pain.
Celecoxib offered analgesic efficacy comparable to loxoprofen for overall pain control in patients with frozen shoulder. Importantly, celecoxib exhibited superior effectiveness in relieving nocturnal pain, suggesting it may be a preferred NSAID option for frozen shoulder pain management, particularly in those experiencing sleep-disrupting symptoms.
Modern Rheumatology
Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder
Satoru Ohta et al.
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