Вітамін В6 (піридоксин) відомий своєю важливою функцією в синтезі нейромедіаторів, таких як дофамін, серотонін і гамма-аміномасляна кислота (ГАМК). Нейропротекторна роль піридоксину пов’язана в основному з його здатністю регулювати глутаматергічну систему і, таким чином, рівні ГАМК і глутамату. Оскільки ГАМК є основним гальмівним нейромедіатором, очевидно, що дефіцит ГАМК може призвести до серйозних наслідків, таких як судоми. Підвищення рівня глутамату - попередника ГАМК, збудливого нейромедіатора, може бути пов’язане з судомами, тоді як застосування ГАМК або піридоксину може припинити судомну активність. Крім основної ролі у виробництві нейромедіаторів, вітамін В6 є важливим для утворення мієліну [2,3].
Люмбоішіалгія (ішіас) – це відомий патологічний стан найбільшого нерва в організмі людини. Люмбоішіалгія, викликана защемленням корінців сідничного нерва та відома багатьом пацієнтам як різновид «радикуліту», через сильний біль та обмеження руху створює значний життєвий дискомфорт [5].
Відомо, що вітаміни групи В, такі як тіамін (В1), піридоксин (В6) та ціанокобаламін (В12), мають антиноцицептивну (знеболюючу) дію при гострих та хронічних ушкодженнях, які супроводжуються больовим синдромом [6].
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Важливо відмітити, що пацієнти з люмбосакральною радикулопатією відчували кращу ефективність лікування змішаного болю при застосуванні вітамінів групи В у поєднанні з диклофенаком, ніж при використанні монотерапії диклофенаком [7]. Для повноцінного відновлення після травматичного впливу при люмбоішіалгії необхідне комплексне лікування, важливим компонентом якого є застосування вітамінів B1, B6 та В12, які не тільки сприяють зменшенню інтенсивності болю, але й чинять регенеруючий вплив на нервову тканину [3,4,8].
Джерела:
1. Baltrusch S. The Role of Neurotropic B Vitamins in Nerve Regeneration. Biomed Res Int. 2021;2021:9968228.
2. Calderon-Ospina CA, Nava-Mesa MO, Paez-Hurtado AM. Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review. Ther Clin Risk Manag. 2020;16:1275-1288.
3. Wu F, Xu K, Liu L, et al. Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury [published correction appears in Front Pharmacol. 2021 Apr 12;12:598335]. Front Pharmacol. 2019;10:406.
4. Altun I, Kuruta EB. Vitamin B complex and vitamin B12 levels after peripheral nerve injury. Neural Regen Res. 2016;11(5):842-845.
5. Zhang Y, Zhang Y, Chen X, et al. Acupoint catgut embedding for the treatment of sciatica: A protocol for a systematic review. Medicine (Baltimore). 2021;100(1):e23951.
6. Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery. Pain Res Treat. 2012;2012:104782.
7. Calderon-Ospina CA, Nava-Mesa MO, Arbelez Ariza CE. Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis. Pain Med. 2020;21(4):766-781.
8. El Soury M, Fornasari BE, Carta G, Zen F, Haastert-Talini K, Ronchi G. The Role of Dietary Nutrients in Peripheral Nerve Regeneration. Int J Mol Sci. 2021;22(14):7417
Витяг з інструкції для медичного застосування препарату: НЕЙРОБІОН (таблетки). Код АТС А11D B. Препарати вітаміну В1 в комбінації з вітаміном В6 та/або вітаміном В12. СКЛАД: 1 таблетка містить тіаміну дисульфіду (вітаміну В1) 100 мг, піридоксину гідрохлориду (вітаміну В6) 200 мг, ціанокобаламіну (вітаміну В12) 240 мкг.
ФАРМАКОДИНАМІКА. Застосування вітамінів B1, B6 та B12 у ряді больових моделей у щурів показало антиноцицептивну активність із переважаючою ефективністю такої комбінації над прийомом окремих компонентів. ПОКАЗАННЯ. Неврологічні захворювання, викликані дефіцитом вітамінів групи B.
СПОСІБ ЗАСТОСУВАННЯ ТА ДОЗИ. Рекомендована доза становить 1 таблетку на добу.
ПРОТИПОКАЗАННЯ. Підвищена чутливість до діючих речовин або до будь-якої з допоміжних речовин; застосування дітям та підліткам через високий вміст активних речовин. Вітамін В6 протипоказано застосовувати при виразковій хворобі шлунка і дванадцятипалої кишки у стадії загострення (оскільки можливе підвищення кислотності шлункового соку). Вітамін B12 протипоказано застосовувати при еритремії, еритроцитозі, тромбоемболії. Вітамін В1 протипоказано застосовувати у пацієнтів з алергічними захворюваннями в разі реакції гіперчутливості на вітамін В1.
ПОБІЧНІ РЕАКЦІЇ. З боку нервової системи, травного тракту, імунної системи, інші. РП № UA/5409/01/01. Наказ МОЗ України від 01.10.2021 № 2128
КАТЕГОРІЯ ВІДПУСКУ. За рецептом. ВИРОБНИК. Пі енд Джі Хелс Острія ГмбХ енд Ко. ОГ, Австрія. Заявник. Пі енд Джі Хелс Джермані ГмбХ, Німеччина.
Інформація для медичного працівника. Перед призначенням ознайомтесь з повним текстом інструкції для медичного застосування лікарського засобу. За додатковою інформацією звертайтесь за адресою: ТОВ «Др. Редді'с Лабораторіз» Столичне шосе, 103, оф. 11-А, м. Київ, Україна, 03131, тел. +380444923173
1NB-06-12-2021-RX2-7.2, ч. 2
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