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Adults with celiac disease face an increased risk of lumbar osteoporosis starting at age 45. Early screening from this age can help prevent fractures and bone complications.
A cross-sectional study led by Azita Ganji et al. highlighted the heightened risk of osteoporosis in individuals with celiac disease, particularly among those aged 45 and above. Researchers aimed to identify the optimal age for initiating osteoporosis screening in this population by stratifying risk based on age.
Approximately 199 adult patients diagnosed with celiac disease were included from 2015 to 2020. Patients younger than 25 and those with endocrine disorders, smoking habits, corticosteroid use, or postmenopausal status were excluded. At diagnosis, all participants underwent a series of evaluations, including intestinal pathology, bone mineral density (BMD) measurement via lumbar densitometry, serum tissue transglutaminase immunoglobulin A (TGA-IgA), and vitamin D levels.
According to the findings, there was a clear disparity across age groups. Osteoporosis was identified in 23.6% of the patients, 74.5% were women, and 25.5% were men. When analyzed across four age groups, the study revealed a significant increase in osteoporosis risk among middle-aged patients. After adjusting for potential confounders, the fully adjusted multivariate model showed that individuals aged 45–55 had a 22% higher chance of developing lumbar osteoporosis when compared to those aged 25–35 (odds ratio: 1.22).
The findings supported a shift in screening time. Experts now recommend starting bone mineral density checks at age 45 in celiac disease patients. This early action could help prevent fractures and improve long-term bone health.
Scientific Reports
Optimal age for screening lumbar osteoporosis in celiac disease
Azita Ganji et al.
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