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An 11-fold rise in diamine oxidase activity during pregnancy is strongly associated with marked symptom relief in women with histamine intolerance.
For women living with histamine intolerance—a condition triggered by low activity of the enzyme diamine oxidase (DAO)—daily life can mean coping with headaches, bloating, skin flare-ups, or even muscle pain. Now, new research led by Adriana Duelo et al. suggests that pregnancy itself may offer natural relief, thanks to a dramatic rise in DAO activity!
A first-of-its-kind prospective observational study tracked 30 women diagnosed with histamine intolerance before, during, and after pregnancy. Investigators measured serum DAO activity at each stage and asked volunteers to report the presence or absence of symptoms across multiple systems, including musculoskeletal, gastrointestinal, circulatory, neurological, respiratory, and dermatological. Unlike other trials, no dietary interventions—such as the typically restrictive low-histamine diet—were prescribed during pregnancy, making the results a true reflection of physiological changes.
The findings were striking!
These results illustrate, for the first time, that the surge in DAO levels during pregnancy is strongly linked with symptom relief in histamine intolerance. The findings suggest that restrictive diets may not be necessary for pregnant women with the condition—a potential shift in clinical management. However, experts caution that the trial involved only 30 women and larger studies are needed to confirm these results. Hence, pregnancy may offer a unique, temporary “reset” for women with histamine intolerance by dramatically boosting DAO activity and easing symptoms—an insight that could guide future therapies beyond dietary restriction.
Journal of Clinical Medicine
Improvement of Histamine Intolerance Symptoms in Pregnant Women with Diamine Oxidase Deficiency: An Exploratory Study
Adriana Duelo et al.
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