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This study sought to assess the effects of a collagen peptide-based dietary supplement (molecular weight 1–3 kDa) on symptoms of knee osteoarthritis (OA) and associated inflammatory markers, specifically C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).
In patients with knee osteoarthritis, oral administration of hydrolyzed collagen alleviates pain and boosts functionality.
This study sought to assess the effects of a collagen peptide-based dietary supplement (molecular weight 1–3 kDa) on symptoms of knee osteoarthritis (OA) and associated inflammatory markers, specifically C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).
Volunteers aged 30 to 81 years (50% female), all diagnosed with grade II or III OA and experiencing moderate-to-severe pain (visual analog scale [VAS] score ≥40 on a 0–100 scale), were enrolled. They were randomly divided into two groups: one received 10 grams of the collagen peptide supplement daily (verum group), while the other received a placebo. Evaluations were executed at the start of the study and again post 6 months.
In this randomized-controlled study, initial comparisons showed no prominent differences between the groups. However, by 6 months, those in the verum group experienced marked improvements across several key outcomes. These encompassed remarkable reductions in pain intensity (VAS), functional impairment (Lequesne algofunctional index [LAI]), and inflammatory markers (CRP and ESR), all with p-values < 0.001 when compared to the placebo group. Importantly, the supplement was well-tolerated, with no reported adverse effects, and illustrated high levels of safety and user acceptability.
Collagen peptide supplementation appears to be a valuable adjunct to conventional treatments for knee OA. It may help relieve joint pain, boost physical function, and potentially reduce dependence on analgesic or anti-inflammatory medications. The study adds to the growing body of evidence supporting the role of nutritional interventions in tackling chronic joint ailments.
Contemporary Clinical Trials Communications
Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study
Juan Antonio Carrillo-Norte et al.
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